Process for producing an optically active .gamma.-hydroxy-L-glut

Details Process for producing an optically active .gamma.-hydroxy-L-glut Process for producing an optically active .gamma.-hydroxy-L-glut

1995-07-11

1997-07-01

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435110, 4352523, 43525231, 43525233, 435280, C12P 1304, C12P 1314, C12P 4100

Patent

active

056437692

ABSTRACT:
An object of the present invention is to provide a process for producing an optically active .gamma.-hydroxy-L-glutamic acid advantageously on an industrial scale. The present invention provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst I, an amino group donor, pyruvic acid and glyoxylic acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active .gamma.-hydroxy-L-glutamic acid therefrom, said biocatalyst I having activity of forming the optically active .gamma.-hydroxy-L-glutamic acid from pyruvic acid and glyoxylic acid in the presence of an amino group donor. The present invention also provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst II, an amino group donor and optically active 4-hydroxy-2-ketoglutaric acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active 4-hydroxy-2-ketoglutaric acid therefrom, said biocatalyst II having activity of converting an optically active 4-hydroxy-2-ketoglutaric acid into the optically active .gamma.-hydroxy-L-glutamic acid in the presence of an amino group donor.

REFERENCES:
J. Am. Chem. Soc. vol. 79 pp. 6192-6198 Benoiton et al Published Dec. 5, 1957.
Adams et al "Biochim. & Biophys. Acta" 77 (1963) 133-135.
Adams et al "Jour. Biol. Chem" vol. 235 No. 12 Dec. 1960 pp. 3504-3512.
Passerat et al "Tetrahed. Letters" vol. 28 #12 pp. 1277-1280 (1980).
"Methods in Enzymology" Metabolism of Amino Acids & Amines vol. XVIIB pp. 274-281 Academic Press ed. Tabor et al 1971.
Methods in Enzymology, vol. 17, No. B, 1970, pp. 266-306, E. Adams, "Enzymes and Intermediates of Hydroxyproline Degradation", pp. 266-268.

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