Biocompatible coated article

Details Biocompatible coated article Biocompatible coated article

1995-06-07

1997-07-01

Nakarani, D. S.

Stock material or miscellaneous articles

Composite

Of polyester

4283155, 4283159, 4283197, 428447, 428451, 428480, B32B 2732, B32B 2736

Patent

active

056436815

ABSTRACT:
The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.

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Zisman, W.A. (1964) Adv. Chem. Ser. 43.
Lovinger et al. (1993) "Morphology and Properties of Polycaprolactone-Poly(dimethyl siloxane)-Polycaprolactone Triblock Copolymers," J. Polymer Sci. Part B (Polymer Physics) 31:115-123.
Gemmell et al. (1995) J. lab. Clin. Med. 125:276-287.
Clarson and Semlyn (eds.) (1993) Siloxane Polymers, "Radiation Cross-Linking of Siloxanes," pp. 606-609.

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