Process for preparing cephalosporins

Details Process for preparing cephalosporins Process for preparing cephalosporins

1980-08-29

1982-04-06

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 16, 544 27, 544 30, C07D50120

Patent

active

043236766

ABSTRACT:
Novel 3-acyloxymethyl-cephem compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group; W is acetonyl, or a group represented by --X--COOH or --X--OH (X is an organic residue) or salts thereof were found to be useful as starting materials for preparing cephalosporins of the formula: ##STR2## wherein R.sup.3 stands for a residue nucleophilic compound and R.sup.1 has the same meaning as above.

REFERENCES:
patent: 3278531 (1966-10-01), Cox et al.
patent: 3929780 (1975-12-01), Weir
patent: 4094978 (1978-06-01), Beeby
patent: 4112087 (1978-09-01), Beeby
patent: 4245088 (1979-06-01), Tsushima et al.
Cephalosporins and Penicillins, 1972, pp. 151-166.
JCS, 1965, pp. 5015-5031 and 7020-7028.

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