Potentiation of the effects of insulin by peptides

Details Potentiation of the effects of insulin by peptides Potentiation of the effects of insulin by peptides

1983-06-06

1985-12-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, A61K 3726, A61K 3700

Patent

active

045580332

ABSTRACT:
Disclosed are novel methods and materials for developing hypoglycemic effects in mammals, including human. A pentadecapeptide ("deletion peptide") having the sequence, NH.sub.2 -Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-COOH, is administered to the mammal contemporaneously with exogenous insulin to generate hypoglycemic effects greater than available through administration of insulin alone. The pentadecapeptide sequence is duplicative of the sequence of amino acid residues in human growth hormone in the region spanning positions thirty-two through forty-six.

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