Process for increasing glycine levels in the brain and spinal co

Details Process for increasing glycine levels in the brain and spinal co Process for increasing glycine levels in the brain and spinal co

1979-05-07

1983-08-09

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 31195

Patent

active

043978665

ABSTRACT:
The level of glycine in the brain and in the spinal cord is regulated by administering a neutral amino acid composition to a human wherein increased or decreased brain and spinal cord levels of glycine is effected when the composition contains increased or decreased amounts of threonine or a precursor of L-threonine. The neutral amino acid composition can be administered alone or concomitantly with a drug which either has the undesirable side effect of suppressing glycine-mediated neurotransmission or whose therapeutic efficacy is enhanced by increasing glycinergic neurotransmission.

REFERENCES:
Merck Index, 7th Ed. (1960), pp. 800, 1043 & 1074-1076.

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