Inhibitors of transpeptidase

Details Inhibitors of transpeptidase Inhibitors of transpeptidase

1982-01-04

1983-08-09

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544359, 546123, 546272, 424250, 424263, 424274, 424256, 260239A, C07D48704

Patent

active

043977847

ABSTRACT:
New .beta.-lactams of the general structure: ##STR1## wherein X=O or S; R represents H, loweralkyl, acyl, aryl, or arylloweralkyl; R' is hydrogen, loweralkoxy, loweralkoxyalkyl, loweralkyl, phenylthio or loweralkylmercapto; R" is hydrogen or loweralkyl; and the broken line represents an optional double bond, and certain esters thereof. All compounds are effective antibacterials.

REFERENCES:
patent: 3875154 (1975-04-01), Rapoport
patent: 3923796 (1975-12-01), Rapoport
patent: 4210661 (1980-07-01), Ponsford et al.
patent: 4262011 (1981-04-01), Christensen et al.
patent: 4281002 (1981-07-01), Christensen et al.
patent: 4298741 (1981-11-01), Christensen et al.
Bose et al.; J. Org. Chem., vol. 39, No. 1, pp. 115-116 (1974).

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