Process for converting 6,6-disubstituted penicillanic acid deriv

Details Process for converting 6,6-disubstituted penicillanic acid deriv Process for converting 6,6-disubstituted penicillanic acid deriv

1979-11-23

1983-08-09

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, 424270, 424246, C07D49904

Patent

active

043977839

ABSTRACT:
6-.beta.-Substituted penicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria, and 6-.beta.-substituted penicillanic acid derivatives wherein the carboxy group is protected by a conventional penicillin carboxy protecting group as useful intermediates leading to said synergistic agents. A process for converting 6,6-disubstituted penicillanic acid derivatives to the corresponding 6-.beta.-substituted penicillanic acid congeners.

REFERENCES:
patent: 4180506 (1979-12-01), Pratt
patent: 4203992 (1980-05-01), Gorden et al.

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