Process for preparing 9-(2-hydroxyethoxymethyl)-guanine

Details Process for preparing 9-(2-hydroxyethoxymethyl)-guanine Process for preparing 9-(2-hydroxyethoxymethyl)-guanine

1987-10-19

1989-05-02

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, 544251, C07D47318, A61K 3152

Patent

active

048269816

ABSTRACT:
There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV ##STR1## wherein a novel compound of the formula I ##STR2## wherein R and R' may be the same or different and represent hydrogen, (C.sub.1 -C.sub.8)acyl or benzyl and R.sub.1 represents (C.sub.1 -C.sub.8)acyl, is hydrolyzed basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II ##STR3## with a compound A--CH.sub.2 --O--CH.sub.2 CH.sub.2 --OR' (A is a leaving group, Q is hydrogen or a leaving group), the novel compound of the formula II and a process for the preparation thereof by means of condensing glyoxal hydrate and a compound of the formula V ##STR4##

REFERENCES:
patent: 4621140 (1986-11-01), Verheyden et al.
patent: 4642346 (1987-02-01), Chan et al.

Affiliated with

Also associated with

Rating

Process for preparing 9-(2-hydroxyethoxymethyl)-guanine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 9-(2-hydroxyethoxymethyl)-guanine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 9-(2-hydroxyethoxymethyl)-guanine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-586085