New derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamin

Details New derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamin New derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamin

1987-12-16

1989-05-02

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562450, 549 57, 549468, 548492, 546169, 514443, 514464, 514419, 514312, C07C10142

Patent

active

048268780

ABSTRACT:
New original derivatives are described of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxobutasnoic acids having the formula: ##STR1## in which n is 1 or 2, R.sub.1 is selected from the groups 2-naphthyl, 2 (or 3)-quinolinyl, 2 (or 3)-indolyl, 2 (or 3)-benzofuranyl, 2 (or 3)-benzothiophenyl, and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 or 5 carbon atoms, preferably pentyl, 2-ethoxyethyl, 3-methoxypropyl or 3-ethoxypropyl.
The compounds have a powerful antagonistic activity towards cholecystokinin and are particularly useful in the treatment of illnesses of the digestive system, such as colitis, biliary diskinesia, pancreatitis or in the treatment of disorders of the central nervous system imputable to deficiencies in the physiological neuron levels of cholecystokinin or other related bioactive polypeptides.

REFERENCES:
patent: 4439617 (1984-03-01), Sestanj et al.
Chemical Abstracts, vol. 103, No. 13, Abstract No. 99103r, Sep. 30, 1985.

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