Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its

Details Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its

1985-12-31

1989-05-02

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 47, 536 26, 536 27, 536 28, 536 29, A61K 3152

Patent

active

048268232

ABSTRACT:
Nucleotide compounds are provided, namely 2-chloro-2'-deoxyadenosine 5'-phosphate compounds (I) especially as the monosodium and disodium salt, as well as a method for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds of the invention have pharmacological properties and are useful antimicrobial agents, antiviral agents, and antileukemic agents. ##STR1##

REFERENCES:
patent: 3201389 (1965-08-01), Fujimoto et al.
patent: 3321463 (1967-05-01), Moffatt
patent: 3337529 (1967-08-01), Laufer
patent: 3466273 (1969-09-01), Sowa et al.
patent: 4167565 (1979-09-01), Stein et al.
Carson et al, I, Proc. Nat. Acap. Sci. USA, vol. 77(11), pp. 6865-6869, 1980.
Carson et al, II, Blood, vol. 62 (4), pp. 737-743, 1983.
Bennett et al, Chem. Abstr., 103:31970r, Aug. 5, 1985.

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