Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-12-20
1996-10-08
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 695, 530385, C07H 1700, C07K 14085, C12P 900, C12P 2106
Patent
active
055632548
ABSTRACT:
The present invention provides for polynucleotides capable of producing recombinant hemoglobins that have a P.sub.50 of 26-36 torr. This invention makes possible the commercial production of wholly artificial hemoglobin, whether conventional or mutant in form, which can be used as blood substitutes.
REFERENCES:
patent: 4301144 (1981-11-01), Iwashita
patent: 4321259 (1982-03-01), Nicolau
patent: 4336248 (1982-06-01), Bonhard
patent: 4377512 (1983-03-01), Ajisaka
patent: 4412989 (1983-11-01), Iwashita
patent: 4473563 (1984-09-01), Nicolau
patent: 4598064 (1986-07-01), Walder
patent: 4600531 (1986-07-01), Walder
patent: 4650786 (1987-03-01), Wong
patent: 4670417 (1987-06-01), Iwasaki
patent: 4710488 (1987-12-01), Wong
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5114932 (1992-05-01), Runge
Schneider et al, "Haemoglobin Titusville . . . " Biochim. Biophys. Acta 400: 365-373 (1975).
Fermi & Perutz/Haemoglobin and Myoglobin/Atlas of Molecular Structures in Biology (1981)Entire Text/Clarendon Press/Oxford.
Bunn & Forget/Hemoglobin: Molecular, Genetic and Clinical Aspects (1986) Entire Text W. B. Saunders Company/Philadelphia.
Beretta A. et al./Haemoglobin Torino--.alpha.43 (CDI) Phenylalanine.fwdarw.Valine/Nature/(1968) 217, 1016-1018.
Rabiner, S. F./Evaluation of a Stroma-Free Hemoglobin Solution for Use as a Plasma Expander/Nature/(1967), 126, 1127-1142.
Thornton, J. M./Disulphide Bridges in Globular Proteins J. Exp. Med./(1981), 151, 261-287/Academic Press Inc./London.
Nagai & Thogersen/Generation of .beta.-Globin by Sequence-Specific Proteolysis of a Hybrid Protein Produced Inescherichia coli/Nature/J. Mol. Biol./(1984) 309, 810-812.
Liebhaber, S. A. et al./Cloning and Complete Nucleotide Sequence of Human 5'-.alpha.-Globin Gene/PNAS/(1980), 77(12), 7054-7058.
Moo-Penn, W. F. et al./Hemoglobin Raleigh (.beta.1 Valine.fwdarw.Acetylalanine). Structural and Functional Characterization/Biochemistry/(1977), 16, 4872-4879.
Moo-Penn, W. F. et al./Hemoglobin Connecticut (.beta.21(B3) ASP.fwdarw.GLY): A Hemoglobin Variant with Low Oxygen Affinity/American J. of Hematology/(1981)/11, 137-145.
Idelson, L. I. et al/New Unstable Haemoglobin (Hb MOSCVA, .beta..gtoreq.(B4) GLY.fwdarw.ASP) Found in the in the USSR/Nature/1974, 249, 768-770.
Gacon, G. et al/Structural and Functional Studies of Hb Rothschild .beta. 37 (C3) TRP.fwdarw.ARG A New Variant of the .alpha..sub.1 .beta..sub.2 Contact/FEBS Letters (1977), 82(2,) 243-246.
Keeling, M. M. et al./Hemoglobin Louisville (.beta.42 (CD1) PHE.fwdarw.LEU): An Unstable Variant Causing Mild Hemolytic Anemia/J. of Clinical Invest./(1971), 50, 2395-2402.
Ogata, K. et al./Hemoglobin Sendagi (.beta.42 PHE.fwdarw.VAL): A New Unstable Hemoglobin Variant Having an Amino Acid Substitution at CD1 of the .beta.-Chain/Hemoglobin/(1986), 10(5), 469-481.
Yeager, A. M. et al./Hemoglobin Cheverly: An Unstable Hemoglobin Associated with Chronic Mild Anemia/Pediatr. Res./(1983), 17, 503-507.
Marinucci, M. et al/Hemoglobin Bologna (.alpha..sub.1 .beta..sub.2 61 (E5) LYS.fwdarw.MET) An Abnormal Human Hemoglobin with Low Oxygen Affinity/Biochimica Et Biophysica Acta/(1981), 668, 209-215.
Garel, M. C. et al./Hemoglobin J Cairo: .beta. 65 (E9) LYS.fwdarw.GLN, A New Hemoglobin Variant Discovered in an Egyptian Family/Biochimica Et Biophysica Acta/(1976), 420, 97-104.
Shih, D. T-B. et al./Hemoglobin Chico [.beta.66(E10)LYS.fwdarw.THR]: A New Variant with Decreased Oxygen Affinity/Hemoglobin/(1987), 11(5), 453-464.
Steadman, J. H. et al./Idiopathic Heinz Body Anaemia: Hb-Bristol (.beta.67 (E11) VAL.fwdarw.ASP)/ British J. of Haematology/(1970), 18, 435-446.
Stamatoyannopoulos, G. et al./Physiologic Implications of a Hemoglobin with Decreased Oxygen Affinity (Hemoglobin Seattle)/The New Eng. J. of Med./(1969), 281(17), 915-919.
Schneider, R. G. et al./Hb Mobile [.alpha..sub.2 .beta..sub.2 73(E17) ASP.fwdarw.VAL]: A New Variant/Biochemical Genetics/(1975), 13(7/8), 411-415.
Jones, R. T. et al./Hemoglobin Vancouver [.alpha..sub.2 .beta..sub.2 73 (E17) ASP.fwdarw.TYR]: Its Structure and Function/J. of Molecular Evolution/(1976), 9, 37-44.
Sugihara, J. et al/Hemoglobin Rahere, A Human Hemoglobin Variant with Amino Acid Substitution at the 2,3-Diphosphoglycerate Binding Site/J. Clin. Invest./(1985), 76, 1169-1173.
Tatsis, B. et al/Hemoglobin Pyrgos .alpha..sub.2 .beta..sub.2.sup.83(EF7)GLY.fwdarw.ASP :A New Hemoglobin Variant in Double Heterozygosity with Hemoglobin S/Blood/(1976), 47(5), 827-832.
Merault, G. et al/Hemoglobin Roseau-Pointe A Pitre .alpha..sub.2 .beta..sub.2 90 (F6) GLU-GLY: A New Hemoglobin Variant with Slight Instability and Low Oxygen Affinity/FEBS Lett./(1985), 184(1), 10-13.
Nagel, R. L. et al/Hemoglobin Beth Israel, A Mutant Causing Clinically Apparent Cyanosis/N. England J. of Med./(1976), 295(3), 125-130.
Efremov, G. D. et al/Hemoglobin Richmond, A Human Hemoglobin which Forms Asymmetric Hybrids with Other Hemoglobins/J. of Biol. Chem./(1969), 244(22), 6105-6116.
Turner, J. W. et al/Characterization of Hemoglobin Burke [.beta.107 (G9) GLY.fwdarw.ARG]/Biochem. Genetics/(1976), 14(7/8), 577-585.
Imamura, T. et al/Hemoglobin Yoshizuka (G10(108).beta. Asparagine.fwdarw.Aspartic Acid): A New Variant with a Reduced Oxygen Affinity from a Japanese Family/J. Clin. Invest/1969,48,2341-2348.
Lawn, R. M. et al/The Nucleotide Sequence of the Human .beta. Globin Gene/Cell/(1980), 21, 647-651.
Ahern, E. et al/Haemoglobin Caribbean .beta.91 (F7) LEU.fwdarw.ARG: A Mildly Unstable Haemoglobin with a Low Oxygen Affinity/FEBS Letters/(1976), 69(1), 99-102.
Bratu, V. et al/Haemoglobin Bucuresti .beta.42 (CDI) PHE.fwdarw.LEU, A Cause of Unstable Haemoglobin Haemoloytic Anaemia/Biochimica Et Biophysica Acta/(1971), 251, 1-6.
Anderson, N. L. et al/Site of the Amino-Acid Substitution in Haemoglobin Seattle (.alpha..sub.2.sup.A .beta..sub.2.sup.70ASP)/Nature/(1973), 243, 274-275.
Blouquit, Y. et al/Structural Study of Hemoglobin Hazebrouck, .beta.38(C4) THR.fwdarw.PRO A New Abnormal Hemoglobin with Instability and Low Oxygen Affinity/FEBS Letts/(1984), 172(2), 155-158.
Dacie, J. V. et al/Haemoglobin Hammersmith (.beta.42 (CDI) PHE.fwdarw.SER)/Nature/(1967), 216, 663-665.
Schoner B./Recombinant DNA/Methods in Enzymology/(1987), 153, 400-417/Edited by Ray Wu, Lawrence Grossman/Academic Press, Inc. San Diego.
Charache, S. et al/Hemoglobin Okaloosa (.beta.48 (CD7) Leucine.fwdarw.Arginine) An Unstable Variant with Low Oxygen Affinity/J. of Clin. Invest./(1973), 52, 2858-2864.
Tait, R. C. et al/The Rapid Purification of T4 DNA Ligase from a .lambda. T4 LIG Lysogen/J. of Bio. Chemistry/(1980)10, 813-815.
Boyer, P. D./Spectrophotometric Study of the Reaction of Protein Sulfhydryl Groups with Organic Mercurials/J. Am. Chem. Soc./(1954),76,4331-4337.
Imai, K. et al/Studies on the Function of Abnormal Hemoglobins/Biochimica Et Biophisica Acta/(1970), 200, 197-202.
Grantham, R. et al/Codon Catalog Usage is a Genome Strategy Modulated for Gene Expresivity/Nucleic Acids Research (1981), 9(1), R43-R74.
Grunstein & Hogness/Colony Hybridization: A Method for the Isolation of Cloned DNAs that Contain a Specific Gene/PNAS-Biochemistry/(1975), 72(10), 3961-3965.
Wilson, J. T. et al/Insertion of Synthetic Copies of Human Globin Genes into Bacterial Plasmids/Nucleic Acids Research/(1978), 5(2), 563-581.
McCracken, A. A. et al/An Enrichment Selection for Mutants Resulting from Oligonucleotide-Directed Mutagenesis of Double-Stranded DNA/Biotechniques(1988), 6(4), 332-339.
MacDonald, V. W. et al/Coronary Vasoconstriction and Maintenance of Normal Myocardial Function with HPLC Purified Hemoglobin Ao and Pasteurized .alpha.--.alpha. Cross Linked Hemoglobin/FASEB Journal/(1988), 2(6), Abstract 8217.
Bove, J. R./Transfusion-Transmitted Diseases: Current Problems and Challenges/Prog. in Hematology/(1986), 14, 123-145.
Gait, M. J. et al/Rapid Synthesis of Oligodeoxyribonucleotides VII. Solid Phase Synthesis of Oligodeoxyribonucleotides by a Continuous Flow Phosphotriester Method on a Kieselguhr-Polyamide Support/Nucleic Acids Res./(1982), 10(20)6243-6254.
Lloyd, S. et al/Rapid Purification of Synthetic O
Hoffman Stephen J.
Nagai Kiyoshi
Brown Theresa A.
Carlson K. Cochrane
Cooper Iver P.
Medical Research Council
Nowak Henry P.
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