Nucleic acid molecule encoding a protein growth factor for inhib

Details Nucleic acid molecule encoding a protein growth factor for inhib Nucleic acid molecule encoding a protein growth factor for inhib

1997-09-11

2000-08-22

Crouch, Deborah

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 536 231, C07H 2104, C07H 2102

Patent

active

061074764

ABSTRACT:
This invention provides proteins which selectively inhibit the proliferation of androgen-independent prostate cancer cells. This invention also provides a nucleic acid molecule encoding the instant proteins, including a nucleic acid molecule suitable for use in gene therapy for treating a subject afflicted with androgen-independent prostate cancer. This invention further provides a composition of matter which selectively kills androgen-independent prostate cancer cells, and comprises the instant proteins and a toxic moiety operably affixed thereto. Finally, the instant invention provides related pharmaceutical compositions and methods for treating androgen-independent prostate cancer.

REFERENCES:
patent: 4886747 (1989-12-01), Derynck et al.
Ross et al. 91996) Human Gene Therapy 7m 1781-1790.
Verma et al. (1997) Nature 389, 239-242.
Miller et al. 91995) FASEB Journal 9, 190-199.
Crystal (1995) Science 270, 404-410.
Blau et al (Nov. 2, 1995) New Eng. J. Med., pp. 1204-1207.
J. Massague, Ann, Rev. Cell. Biol., 1990,6:597-641, The Transforming Growth Factor -.beta. Family.
N. M. Greenberg, et al., P.N.A.S. U.S.A. 92:3439-3443 (1995), Prostate Concer in a Transgenic Mouse.
T. C. Thompson, et al., Cancer 71: 1165-1171 (1993) Transgenic Models for the Study of Prostate Cancer.
Usui et al, J. Neurosci.,14(8): 4915-4926, 1994 Isolation of Clones of Rat Striatum-Specific mRNAs.
Altschul et. al., J.Mol.Biol., 215:40, (1990), Basic Local Alignment Search Tool.
Pearson & Lipman, PNAS, 85:2444, 1988, Improved Tools for Biological Sequence Comparison.
Frohman et. al, PNAS 85:8998-9002; 1988, Rapid Production of Full-Length cDNAs.
Graham and van der Eb, Virology 52:456 (1973), A New Technique for the Assay of Infectivity.
S. Subramani, et al., Mol & Cell. Biol., Sep. 1981, p. 854-864, Expression of the Mouse Dihydrofolate.
Towbin et al., PNAS, 76, 4350 (1979) Electrophoretic Transfer of Proteins from Polyacrylamide.
M. Kozak, J. Biol. Chem., vol. 266, No. 30, 19867-19870 (1991), Structural Features in Eukaryotic mRNAs.
Hosaka, et al., J. Biol, Chem., vol. 266, pp 12127-12130 (1997) Arg+X-Lys/Arg-Arg Motif As A Signal.

Affiliated with

Also associated with

Rating

Nucleic acid molecule encoding a protein growth factor for inhib does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid molecule encoding a protein growth factor for inhib, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecule encoding a protein growth factor for inhib will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-582611