Process for the preparation of 5-(trifluoromethyl)-uracil, and t

Details Process for the preparation of 5-(trifluoromethyl)-uracil, and t Process for the preparation of 5-(trifluoromethyl)-uracil, and t

1993-07-02

1994-10-04

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544313, 544334, 20415772, C07D23902

Patent

active

053527879

ABSTRACT:
5-Trifluoromethyl-uracil is obtained by chlorinating thymine under mild conditions, further chlorinating the resulting 2,4-dichloro-5-methyl-pyrimidine under drastic conditions to give 2,4-dichloro-5-trichloromethylpyrimidine, reacting the latter with a fluorinating agent to give 2,4-fluorinated and/or -chlorinated 5- trifluoromethylpyrimidines and subjecting these to hydrolysis. The novel chemical compounds 2,4-dichloro- 5-trichloromethylpyrimidine and 2,4-difluoro-5-trifluoromethylpyrimidine are obtained in the course of this process.

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