Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1992-08-31
1994-10-04
Cashion, Jr., Merrell C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530343, C07K 112, C07K 310
Patent
active
053527712
ABSTRACT:
The present invention provides a method for the selective cleavage of peptide amide bonds under ambient conditions by treating a peptide comprising the subunit --CO--NH--CH((CH.sub.2).sub.x SY)CONH-- wherein x is 1-2 and Y is H or (C.sub.1 -C.sub.4)alkyl in an aqueous medium with a tetracoordinate Pd(II) or tetracoordinate Pt(II) complex which promotes the hydrolysis of the adjacent amide bond proximal to the carboxy terminus of the subunit.
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Kostic Nenad M.
Zhu Longgen
Cashion Jr. Merrell C.
Huff Sheela J.
Iowa State University & Research Foundation, Inc.
Woessner Warren D.
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