Poly(ethylene or propylene glycol)-containing polymer

Details Poly(ethylene or propylene glycol)-containing polymer Poly(ethylene or propylene glycol)-containing polymer

1993-06-11

1994-10-04

Kight, III, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525539, 528296, 528304, 528312, 528320, C08G 6348, C08G 6312

Patent

active

053527569

ABSTRACT:
A crosslinked poly(ethylene or propylene)glycol-containing polymer which has a unique spatial structure and can be designed especially for application as a chromatographic resin or as a solid support for the synthesis of peptides, oligonucleotides or oligosaccharides or as a substrate for the immobilization of proteins. The polymer is formed by radical copolymerization of derivatized poly(ethylene or propylene) glycol bis-end substituted with a moiety selected from the group consisting of acryloylalkyl, acryloylaryl, acrylamidoalkyl and acrylamidoaryl with an acrylic amide, nitrile or ester. When it is to be used as a solid support or immobilization substrate, the polymer will incorporate a spacer comprising functional groups for the attachment of peptides, proteins, nucleotides or saccharides such as those selected from the group consisting of amino, alkylamino, hydroxy, carboxyl, mercapto, sulfeno, sulfino, sulfo and derivatives thereof.

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patent: 5087690 (1992-02-01), Demarey
patent: 5130405 (1992-07-01), Walker et al.
Daniels, S. B. et al. "Membranes as Solid . . . " Tetrahedron Letters, 1989, vol. 30, No. 33, pp. 4345-4348.GB.
Small, P. et al. "Design and Application of a New . . . " Journal of the Chemical Society, Chemical Communications, 1989, No. 21, pp. 1589-1591.
Meldal, M. "Pega: A Flow Stable Polyethylene . . . " Tetrahedron Letters, 1992, vol. 33, No. 21, pp. 3077-3080 G.B.

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