Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-02-04
1994-10-04
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514913, A61K 3119
Patent
active
053527020
ABSTRACT:
A method for treating glaucoma in an eye of a human patient is disclosed. The method comprises the step of chronically, orally administering to the patient an unsaturated ketone derivative of an aryloxyacetic acid in an amount sufficient to safely and effectively lower intraocular pressure in the human eye. The unsaturated ketone derivative is selected from the group consisting of ethacrynic acid, an analog of ethacrynic acid, an ester derivative of ethacrynic acid, an ester derivative of an ethacrynic acid analog, an amide derivative of ethacrynic acid, an amide derivative of an ethacrynic acid analog, a pharmaceutically acceptable salt of ethacrynic acid, a pharmaceutically acceptable salt of an ethacrynic acid analog, a pharmaceutically acceptable salt of the ester derivative, a pharmaceutically acceptable salt of the amide derivative, and mixtures thereof. The amount administered is preferably between about 50 mg and about 75 mg two times per day.
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Chemical Abstract 117 (19):18 4817 K (1992), Liang et al.
Edecrin Product Sheet, Merck & Co., Inc., Oct. 1985.
Investigative Opthalmology & Visual Science, Mar. 15, 1991, vol. 32, No. 4, Abstract 992-45, Association for Research in Vision & Opthalmology.
American Journal of Opthalmology, vol. 66, Jul.-Dec., 1968 pp. 680-683, Jose D. Peczon, M.D. & W. Morton Grant, M.D.
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