Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-26
1994-10-04
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514910, A61K 3144
Patent
active
053526864
ABSTRACT:
The present invention is directed to the use of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines in the manufacture of a medicament for producing an orexigenic effect.
REFERENCES:
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Psychiatric Developments, vol. 1, No. 3, 1983, K. A. Halmi: The State of Research in Anorexia Nervosa and Bulimia, pp. 247-262.
Annals of the New York Academy of Sciences, vol. 600, The Neuropharmacology of Serotonin, Serotonin and Appetite, G. Curzon, pp. 521-531 (1990).
Annals of the New York Academy of Science, vol. 600, The Neuropharmacology of Serotonin, Serotonin in Human Eating Disorders, David C. Jimerson, et al, pp. 532-545 (1990).
Hibert et al, Conformation-Activity Relationship Study of 5-HT.sub.3 Receptor Atagonists and a Definition of a Model for this Receptor Site, J. Med. Chem. (1990) 33, 1594-1600.
Boudreaux William R.
Cintins Marianne M.
Criares T. J.
Dixon J. Michael
Merrell Dow Pharmaceuticals Inc.
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