Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-02-14
1994-10-04
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 530317, 530326, A61K 3702, C07K 710
Patent
active
053526597
ABSTRACT:
Disclosed are a peptide represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein M represents a mercaptoacyl group; P, Q, R, S, T, U, V, W, X, Y and Z each represent amino acid residues, wherein an amino acid side chain of Y is either a substituted saturated aliphatic hydrocarbon group having 1 to 15 carbon atoms or an unsubstituted saturated aliphatic hydrocarbon group having 4 to 15 carbon atoms other than (1S)-1-methylpropyl; (2) a method for producing the above-mentioned peptide or the salt thereof, which comprises subjecting a peptide represented by formula (II) or a salt thereof to an oxidation reaction:
REFERENCES:
M. Yanigisaw et al., "A Novel Potent Vasoconstrictor Peptide Produced By Vascular Endothelial Cells", Nature, 332, (1988), pp. 411-415.
A. Inoue et al, "The Human Endothelin Family" Proc. Nat'l. Acad. Sci. USA, 86, (1989) pp. 2863-2867.
C. Hiley et al., "Pressor Effect of Endothelin-1 and Some Analogs in the Perfused Superior Mesenteric Arterial Bed of the Rat" J. Cardiovascular Pharmacology 13, Supp. 5, S197-S199 (1989).
K. Nakajima et al., "Structure-Activity Relationship of Endothelin" Biochemical And Biophysical Research Communications 163(1), (1989) pp. 424-429.
A. Bdolah et al., "SRTX-d, a new native peptide of the endothelin/sarafatoxin family", FEBS Letters, 256(1,2) (1989) pp. 1-3.
R. de Castiglione et al., "Alanine Scan of Endothelin", in Peptides, Chemistry and Biology, Smith and Rivier (eds.) proc. of the 12th American Peptide Symposium (1992) pp. 402-403.
Erhardt, Paul, Endothelin, Chapter 4, p. 52, (Edited by Ruthwayi), 1992, Oxford Press
Kikuchi Takashi
Kubo Kazuki
Wakimasu Mitsuhiro
Conlin David G.
Eisenstein Ronald I.
Lee Lester L.
Takeda Chemical Industries
LandOfFree
Endothelin analogs and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Endothelin analogs and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin analogs and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-581329