Non-crystalline cefuroxime axetil solid dispersant, process for

Details Non-crystalline cefuroxime axetil solid dispersant, process for Non-crystalline cefuroxime axetil solid dispersant, process for

1999-09-16

2000-08-22

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31545

Patent

active

061072907

ABSTRACT:
A non-crystalline cefuroxime axetil solid dispersant showing no absorption peak on a Differential Scanning Calorimetry scan is prepared by (a) dissolving cefuroxime axetil and a surfactant in an organic solvent; (b) suspending a water-insoluble inorganic carrier in the resulting solution; and (c) drying the resulting suspension to remove the organic solvent, said solid dispersant having an improved bioavailability and stability of cefuroxime axetil and being useful for the preparation of a pharmaceutical composition for oral administration.

REFERENCES:
patent: 4865851 (1989-09-01), James et al.
patent: 4994567 (1991-02-01), Crisp et al.
patent: 5013833 (1991-05-01), Crisp et al.

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