Nucleic acids encoding hematopoietic stem cells receptors flk-1

Details Nucleic acids encoding hematopoietic stem cells receptors flk-1 Nucleic acids encoding hematopoietic stem cells receptors flk-1

1992-09-17

1994-02-01

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 530350, 530403, C07H 2100

Patent

active

052833542

ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1(flk-2) and FIG. 2 (flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1(flk-2) and FIG. 2 (flk-1); ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.

REFERENCES:
A. F. Wilks PNAS 86:1603-1607 Mar. 1989.
W. Matthews et al. PNAS 88:9026-9030 Oct. 1991.
R. Sarzani et al. Biochem Biophys Res Comm. 186(2) 706-714 Jul. 31, 1992.
B. Millauer et al. Cell 72:835-846 1993.
B. Terman et al. Biochem Biophys Res Comm. 187(3) 1579 1992.

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