Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Patent
1996-09-27
2000-08-22
Housel, James C.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
435 4, 435 71, 435 72, 435 793, G01N 33543
Patent
active
061071048
ABSTRACT:
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells. Further provided are methods to identify proteins which interact with AKAP 79, and methods to identify inhibitors of AKAP 79 interaction with other proteins.
REFERENCES:
patent: 4766046 (1988-08-01), Abra et al.
patent: 5169637 (1992-12-01), Lenk et al.
patent: 5180713 (1993-01-01), Abra
patent: 5185154 (1993-02-01), Lasic et al.
patent: 5204112 (1993-04-01), Hope et al.
patent: 5252263 (1993-10-01), Hope et al.
Kuno et al, "Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (Calcineurin A)", Biochem. Biophys. Res. Commun., vol. 165, No. 3, pp. 1352-1358, 12-29-8.
Giri et al, "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (Calcineurin) catalytic subunit", Biochem. Biophys. Res. Commun., vol. 181, No. 1, pp. 252-258, 11-27-9.
Allen et al., "Cyclosporin: A Therapy for Wegner's Granulomatosis" in ANCA--Associated Vasculitides: Immunological and Clinical Aspects, Gross (ed.) New York: Plenum Press (1993), pp. 473-476.
Belldegrun et al., "Interferon-.alpha. Primed Tumor-Infiltrating Lymphocytes Combined with Interleukin-2 and Interferon-.alpha. as Therapy for Metastatic Renal Cell Carcinoma", J. Urol. 150:1384-1390 (1993).
Billingsley et al., "Identification of Calmodulin-Binding Proteins," Meth. Enzymol. 184:451-467 (1990).
Bougneres et al., "Limited Duration of Remission of Insulin Dependency in Children with Recent Overt Type I Diabetes Treated with Low-Dose Cyclosporin", Diabetes 39:1264-1272 (1990).
Bougneres et al., "Factors Associated With Early Remission Of Type I Diabetes In Children Treated With Cyclosporine", N.Eng.J.Med. 318:663-670 (1988).
Bruton and Koeller, "Recombinant Interleukin-2", Pharmacotherapy 14:635-656 (1994).
Brynskov, "Cyclosporin in Crohn's disease", Dan.Med.Bull. 41:332-344 (1994).
Carr et al., "Localization of the cAMP-dependent Protein Kinase to the Postsynaptic Densities of A-Kinase Anchoring Proteins", J.Biol.Chem. 267:16816-16823 (1992).
Carr et al., "Interaction of the Regulatory Subunit (RII) of cAMP-dependent Protein Kinase with RII-anchoring Proteins Occurs through an Amphipathic Helix Binding Motif*", J.Biol.Chem. 266:14188-14192 (1991).
Carr et al., "Association of the type II cAMP-dependent Protein Kinase with a Human Thyroid RII-anchoring Protein", J.Biol.Chem. 267:13376-13382 (1992).
Carr et al., "Follicle-stimulating Hormone Regulation of A-kinase Anchoring Proteins in Granulosa Cells*", J.Biol.Chem. 268:20729-20732 (1993).
Cheley et al., "Type II Regulatory Subunites of cAMP-dependent Protein Kinase and Their Binding Proteins in the Nervous System of Aplysia californica*", J.Biol.Chem. 269:2911-2920 (1994).
Choi and Targan, "Immunomodulator Therapy in Inflammatory Bowel Disease", Dig.Dis and Sci. 39:1885-1892 (1994).
Clipstone and Crabtree, "Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation", Nature 357:695-697 (1992).
Coghlan, V. et al., "Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein", Science 267:108-111 (1995).
Coghlan et al., "Cloning and Characterization of AKAP 95, a Nuclear Protein That Associates with the Regulatory Subunit of Type II cAMP-dependent Protein Kinase*", J.Biol.Chem. 269:7658-7665 (1994).
Cooper et al., "Atopic Dermatitis: Recent Trends in Pathogenesis and Therapy", J.Invest.Derm 102:128-137 (1994).
Cuellar et al., "Treatment of psoriatic arthritis", Ballier's Clin.Rheum. 8:483-498 (1994).
Cyert and Thorner, "Calcineurin-like Activity in Saccharomyces cerevisiae", J.Cell.Biol. 107:841a (1989).
de Groen et al., "Central Nervous System Toxicity After Liver Transplantation", N.Eng.J.Med. 317:861-866 (1987) [Page numbers cited as "861-566" on p. 72].
DeCamilli et al., "Heterogeneous Distribution of the cAMP Receptor Protein RII in the Nervous System: Evidence for Its Intracellular Accumulation of Microtubules, Microtubule-organizing Centers, and in the Area of the Golgi Complex", J.Cell.Biol. 103:189-203 (1986).
Deeg et al., "Cyclosporine as Prophylaxis for Graft-Versus-Host Disease: A Randomized Study in Patients Undergoing Marrow Transplantation for Acute Nonlymphoblastic Leukemia", Blood 65:1325-1334 (1985).
Dillman, "The Clinical Experience with Interleukin-2 in Cancer Therapy", Cancer Biotherapy 9:183-209 (1994).
Dougados and Torley, "Efficacy of Cyclosporin A in Rheumatoid Arthritis: Worldwide Experience", Br.J.Rheum 32(suppl 1):57-59 (1993).
Durfee et al., "The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit", Genes and Development 7:555-567 (1993).
Eichholtz et al., "A Myristoylated Pseudosubstrate Peptide, a Novel Protein Kinase C Inhibitor*", J.Biol.Chem 268:1982-1986 (1993).
Eidelman et al., "Neurologic Complications of FK 506", Transplant.Proc. 23:3175-3178 (1991).
Elliot and Chase, "Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide", Diabetologia 34:362-365 (1991).
Ellis et al., "Cyclosporine Improves Psoriasis in a Double-blind Study", JAMA 256:3110-3116 (1986).
Feldt-Rasmussen et al., "Oral cyclosporine for severe chronic idiopathic urticaria and angioedema", Diabetes Medicine 7:429-433 (1990).
Feutren et al., "Cyclosporin Increases The Rate And Length Of Remissions In Insulin-Dependent Diabetes Of Recent Onset", Lancet 2:119-124 (1986).
Feutren, "Renal Morphology After Cyclosporin A Therapy In Rheumatoid Arthritis Patients," Br.J.Rheum. 32(suppl 1):65-71 (1993).
F.o slashed.rre et al., "An Open, Controlled, Randomized Comparison Of Cyclosporine And Azathioprine In The Treatment Of Rheumatoid Arthritis: A Preliminary Report", Arthritis Reheum. 30:88-92 (1987).
Fradin et al., "Oral cyclosporine for severe chronic idiopathic urticaria and angioedema", J.Am.Acad.Derm. 25:1065-1067 (1991).
Fung et al., "Adverse Effects Associated With the Use of FK 506", Transplant.Proc. 23:3105-3108 (1991).
Glantz et al., "Characterization of Distinct Tethering and Intracellular Targeting Domains in AKAP75 a Protein That Links cAMP-dependent Protein Kinase II.beta. to the Cytoskeleton*", J.Biol.Chem. 268:12796-12804 (1993).
Glantz et al., "cAMP Signaling in Neurons: Patterns of Neuronal Expression and Intracellular Localization for a Novel Protein, AKAP 150, that Anchors the Regulatory Subunit of cAMP-Dependent Protein Kinase II.beta.", Mol.Cell.Biol. 3:1215-1228 (1992).
Griffith et al., "X-Ray Structure of Calcineurin Inhibited by the Immunophilin-Immunosuppressant FKBP12-FK506 Complex," Cell 82:507-522 (1995).
Guerini and Klee, "Cloning of human calcineurin A: Evidence for two isozymes and identification of a polyproline structural domain", Proc.Natl.Acad.Sci. (USA) 86:9183-9187 (1989).
Haddy et al., "Inhibition of calcineurin by cyclosporin A-cyclophilin requires calcineurin B," FEBS 314:37-40 (1992).
Hafner et al., "Mechanism of Inhibition of Raf-1 by Protein Kinase A," Mol. Cell Biol. 14:6696-6703 (1994).
Harlow and Lane, "Immunoaffinity Purification of Antibodies on an Antigen Column", in Antibodies: A Laboratory Manual, Harlow and Lane (eds.) Cold Spring Harbor Laboratory:Cold Spring Harbor, NY (1988), pp. 313-318.
Hausken et al., "Type II Regulatory Subunit (RII) of the cAMP-dependent Protein Kinase Interaction with A-kinase Anchor Proteins Requires Isoleucines 3 and 5*", J.Biol.Chem. 269:24245-24251 (1994).
Haydon and Haynes, "New immunosuppressive treatment in transplantation medicine," Ballier's Clin. Gastroentero. 8:455-464 (1994).
Hirsch et al., "Cloning and Expression of an Intron-less Gene for AKAP 75, an Ancho
Gallatin W. Michael
Howard Monique L.
Lai Yvonne
Lockerbie Robert Owen
Housel James C.
ICOS Corporation
Swartz Rodney P.
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