Process for the preparation of pyrrole derivates

Details Process for the preparation of pyrrole derivates Process for the preparation of pyrrole derivates

1993-03-16

1994-03-01

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D207323, C07D207325, C07D207327

Patent

active

052909476

ABSTRACT:
The present invention relates to a process for the preparation of pyrrole derivatives of the general formula I ##STR1## by reaction of a compound of the general formula III ##STR2## where R, R.sup.1 and R.sup.2 are defined as specified in claim 1, in a Vilsmeier reaction. The reaction is carried out in an easily degradable solvent, the reaction product is isolated with the aid of a water-miscible extractant and is purified by high-vacuum distillation in the short path evaporator.

REFERENCES:
patent: 4002643 (1977-01-01), Carson
patent: 4792568 (1988-12-01), Auerbach
patent: 4837225 (1989-06-01), Zoller et al.
patent: 4996901 (1990-10-01), Zoller et al.
patent: 5043348 (1991-08-01), Zoller et al.
March, "Advanced Organic Chemistry", 2nd Ed. (1977) p. 493; McGraw-Hill.
Hinman et al., "Methylpyrrols-Synthesis and Characterization", Journal of Organic Chem., vol. 28 (1963), pp. 3052-3058.

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