Process for the manufacture of brofaromine and analogs thereof

Details Process for the manufacture of brofaromine and analogs thereof Process for the manufacture of brofaromine and analogs thereof

1992-10-14

1994-03-01

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40104

Patent

active

052909395

ABSTRACT:
A process for the manufacture of brofaromine and analogues thereof by reaction of a trisubstitued phosphonium methyl dihydroquinone compound with a 1-(substituted carbonyl)-4-(substituted carbonyl)-piperidine with subsequent cyclization and hydrolysis of the remaining carbonyl substituent. The resulting prmary compound can be further interconverted between free and salt forms or between different salt forms as desired.

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