Process for preparing 2',3'-dideoxyadenosine

Details Process for preparing 2',3'-dideoxyadenosine Process for preparing 2',3'-dideoxyadenosine

1989-03-01

1994-03-01

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 553, C07H 19173, C07H 19073

Patent

active

052909271

ABSTRACT:
A process for preparing 2',3'-dideoxyadenosine of the formula ##STR1## wherein B is adenine, wherein R.sup.1 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl, or silyl, said process comprising:

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House et al. J. Amer. Chem. Soc. 80:182-187 (1958).
Jain et al. J. Org. Chem. 38(18):3179-3186 (1973).
March, Jerry, (1977) Advanced Organic Chemistry: Reactions, Mechanisms and Structure (McGraw-Hill: New York), pp. 944-945.
Robins et al. (1977) Can. J. Chem. vol. 55, pp. 1251-1259.
Robins et al. (1984) Tetrahedron Letters, vol. 25, No. 4, pp. 367-370.
Fieser and Fieser, Reagents for Organic Synthesis, pp. 1292-1293 (1967).

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