Method of preparing isomers of bis isoquinolinium compounds

Details Method of preparing isomers of bis isoquinolinium compounds Method of preparing isomers of bis isoquinolinium compounds

1981-04-13

1985-01-01

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424258, 546147, C07D40110, A61K 3147

Patent

active

044916655

ABSTRACT:
This invention provides the neuromuscular blocking agents of formula (I): ##STR1## where B and C are each a group of formula (II) and are meta or para to one another: ##STR2## wherein D is CH.sub.2 CH.sub.2 or CH.dbd.CH (preferably trans); Y is alkyl of 1-4 carbon atoms (methyl, ethyl, propyl or butyl); E and F and H or OCH.sub.3 ; X.sup.- is an anion, preferably pharmaceutically acceptable; and the substituted benzyl and substituted propyl groups are in a trans relationship relative to each other in the nitrogen-containing ring.
Methods for preparing the compounds, pharmaceutical formulations containing the compounds, and their use are also described.

REFERENCES:
patent: 3004031 (1961-10-01), Taylor et al.
patent: 4179507 (1979-12-01), Stenlake et al.
patent: 4192877 (1980-05-01), Savarese et al.
patent: 4235906 (1980-11-01), Savarese et al.

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