Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1983-05-26
1985-01-01
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 41, 536 182, 536 187, 536 55, 549291, C07H 1504, C07H 506
Patent
active
044916590
ABSTRACT:
Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II, III and IV to known lactone V which is known to be useful via acid VI in the total synthesis of thienamycin (VII): ##STR1## wherein R.sup.1 is hydrogen or a removable protecting group; R is a removable protecting group.
REFERENCES:
patent: 3480613 (1969-11-01), Walton
patent: 3496196 (1970-02-01), Suami et al.
Kametani et al., "Jour. of the American Chemical Society", vol. 102, No. 6, Mar. 12, 1982, pp. 2060-2064.
Arther Thomas E.
Brown Johnnie R.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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