Process for producing antibodies to hepatitis virus and cell lin

Details Process for producing antibodies to hepatitis virus and cell lin Process for producing antibodies to hepatitis virus and cell lin

1983-07-26

1985-01-01

Hazel, Blondel

Chemistry: molecular biology and microbiology

Spore forming or isolating process

424 85, 424 86, 935103, 4351722, C12N 500, C12N 1500

Patent

active

044916329

ABSTRACT:
Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibodies to individual antigenic determinates unique to hepatitis virus.

REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
Diamandopoulous, B. T., Journal of the National Cancer Institute, vol. 50, p. 1347, (1978).
Raschke, V. V. C., Curr. Top. Microbiol. Immunol., vol. 81, p. 70, (1978).
Galfre et al., Nature, vol. 277, pp. 131-133, 1979.
The Lancet, Editorial, pp. 1242-1243, Jun. 11, 1977.

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