Using allosteric hemoglobin modifiers to decrease oxygen affinit

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514512, 514513, 514533, 514535, 514538, 514486, 514833, 548403, 548478, 548416, 548473, 560 30, 560 31, 560 32, 568452, 568455, A61K 3140, A61K 31325, C07C 4500

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052908038

ABSTRACT:
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.

REFERENCES:
patent: 5122539 (1992-06-01), Abraham et al.

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