Tetrahydro-quinolinyl/isoquinolinyl-terminal alkylamino ethynyl

Details Tetrahydro-quinolinyl/isoquinolinyl-terminal alkylamino ethynyl Tetrahydro-quinolinyl/isoquinolinyl-terminal alkylamino ethynyl

1995-06-01

1996-10-08

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514309, 514311, 514312, 546141, 546142, 546144, 546145, 546146, 546153, 546155, 546157, 546172, 546173, 546175, A61K 3147, C07D21514, C07D21716

Patent

active

055631541

ABSTRACT:
Compounds characterized generally as tetrahydro-quinolinyl or tetrahydro-isoquinolinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein G is a tetrahydro-quinolinyl or tetrahydro-isoquinolinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from

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