Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1976-03-26
1978-03-21
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 26, C07D50136, A61K 31545
Patent
active
040804518
ABSTRACT:
A series of novel 7-(D.alpha.-aminophenylacetamido)- and 7-(D-.alpha.-hydroxyphenylacetamido)- .DELTA..sup.3 -cephem derivatives have been prepared wherein a heterocyclic thiomethyl moiety is located at the 3-position of the molecule. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-positive and Gram-negative bacteria. Preferred members include 7-(D-.alpha.-hydroxyphenylacetamido)-3-(3-carbamoyl-1,2,4-triazol-5-yl)thi omethylceph-3-em-4-carboxylic acid and 7-(D-.alpha.-hydroxyphenylacetamido)-3-(2-carboxymethoxy-methyl-1,3,4-thia diazol-5-yl)thiomethylceph-3-em-4-carboxylic acid. Alternative methods of preparation are provided for these compounds, including various synthetic routes leading to the required novel heterocyclic thiol intermediates.
REFERENCES:
patent: 3855213 (1974-12-01), Dunn et al.
patent: 3943129 (1976-03-01), Berges
patent: 3946005 (1976-03-01), Berges
patent: 3998818 (1976-12-01), De Marinis
patent: 4007173 (1977-02-01), Hoover et al.
Baxter Charles Andrew Raymond
Shroot Braham
Pfizer Inc.
Rizzo Nicholas S.
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