Tricyclic antidepressant drug immunogens, antibodies, labeled co

Details Tricyclic antidepressant drug immunogens, antibodies, labeled co Tricyclic antidepressant drug immunogens, antibodies, labeled co

1982-10-21

1985-01-22

Schain, Howard E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

260112R, 260112B, 2601125R, 260121, 424 85, 424 88, 435188, 436528, 436536, 544 47, A61K 39385, C07G 700, C12N 996, G01N 3354

Patent

active

044952813

ABSTRACT:
Tricyclic antidepressant drug (e.g., imipramine, desipramine, amitriptyline, or nortriptyline) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining such drug. The immunogens comprise the drug coupled at its 2'-position to an immunogenic carrier material. Similarly, the labeled conjugates and synthetic intermediates are 2'-derivatives of the drug or a precursor thereof. The antibodies and labeled reagents are particularly useful in certain homogeneous nonradioisotopic immunoassays for measuring tricyclic antidepressant drugs in biological fluids such as serum.

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