Iron-pyridone complexes for anemia

Details Iron-pyridone complexes for anemia Iron-pyridone complexes for anemia

1995-02-17

2000-08-22

Berch, Mark L

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514814, 546 6, C07D21369, A61K 31555

Patent

active

RE0368318

ABSTRACT:
Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.

REFERENCES:
patent: Re34313 (1993-07-01), Hider et al.
patent: 3016372 (1962-01-01), Krimmel
patent: 4550101 (1985-10-01), Hider et al.
patent: 4587240 (1986-05-01), Hider et al.
patent: 4666927 (1987-05-01), Hider et al.
patent: 4840958 (1989-06-01), Hider et al.
patent: 4912118 (1990-03-01), Hider et al.
patent: 5104865 (1992-04-01), Hider et al.
patent: 5177068 (1993-01-01), Callingham et al.
"Organic Chemistry, 3rd Ed" Hendrickson et al, p. 134-135 (1994).
"Introduction to Organic Chemistry, 2nd Edition", Streetweiser, Jr et al, 2 unnumbered pages (1981).
Hashiguchi et al., Molecular Pharm., 13, 362-367, 1977.
Bartulin, Bol. Soc. Chil. Quim, 27, 122-124 (and translation), 1982.
Bartulin, Chemical Abstracts, vol. 97 p. 748, No. 92048a, Columbus, Ohio, USA; 122-124, 1982.
Hare et al, Journal of Medicinal Chemistry, vol. 17, No. 1, , pp. 1-5, Jan. 1974.
Berson et al, Journal of the American Chemical Society, 78, p. 622, 1956.
Yasue et al, Yakugaku Zasshi (Journal of Pharmacology), 90, p. 1222, (and translation), 1970.
Tamhina and Herak, Croatica Chemica Acta CCACAA, 45, p. 603, 1973.
Ward and Harris, Australian Journal of Biological Sciences, 29, p, 189, 1976.
Pitt and Gupta, Development of Iron Chelators for Clinical Use, Anderson and Hiller,Ed, p. 137, (Symp. Proc., Bethesda, Md), Sep. 1975.
Howlin et al, Chemical Abstracts, 1982, vol. 97, No. 173875v and Howlin J. Chem. Soc. Dalton Trans. pp. 1433-1438, 1982.
Mentasti et al, Chemical Abstracts, 1977, vol. 87, No. 157681s and Mentasti Annali di Chimica, vol. 66, pp. 401-415, 1976.
H. Hashiguchi et al. "Inhibition of two copper-containing enzymes, . . . " Molecular Pharmacology, 13, pp. 362-367.
J.M. Petersen et al. "The chemistry of Endialone" Det Kongelige DanskeVidenskabernes Selskab Matematisk-fysiske Meddelelser 36, 5, 1-23 (1967).

Affiliated with

Also associated with

Rating

Iron-pyridone complexes for anemia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iron-pyridone complexes for anemia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iron-pyridone complexes for anemia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-567115