Aryl substituted pyrido[1,4]benzodiazepines for treatment of dep

Details Aryl substituted pyrido[1,4]benzodiazepines for treatment of dep Aryl substituted pyrido[1,4]benzodiazepines for treatment of dep

1984-01-13

1985-01-22

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3155

Patent

active

044951833

ABSTRACT:
Pyrido[1,4]benzodiazepines having antidepressant activity of the formula ##STR1## wherein Ar is 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or a substituted phenyl; R is hydrogen, loweralkyl or an amine on the end of a hydrocarbon chain; Z is hydrogen, halogen, trifluoromethyl, loweralkyl, lower-alkoxy, hydroxy or nitro; and Y is hydrogen, loweralkyl, loweralkoxy or hydroxy; and the pharmaceutical salts are prepared from [2-[(aminopyridinyl)amino]phenyl]arylmethanones which also have antidepressant activity.

REFERENCES:
Chemical Abstracts, 79:53388v, (1973), [Japan 73,11,110, Ozawa et al., 4/10/73].
Chemical Abstracts, 84:164876a, (1976), [Japan Kokai, 7606,991, Kobayashi et al., 1/20/76].

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