Substituted quinoxaline-2-ones as glutamate receptor antagonists

Details Substituted quinoxaline-2-ones as glutamate receptor antagonists Substituted quinoxaline-2-ones as glutamate receptor antagonists

1998-05-15

2000-01-18

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514249, 544295, 544337, 544354, 544230, A61K 31495, C07D24144, C07D40310

Patent

active

06015800&

ABSTRACT:
A novel series of substituted quinoxaline 2-ones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate receptor antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, seizure disorders, pain, Alzheimer's, Parkinson's, and Huntington's Diseases.

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