Serine protease inhibitors-cycloheptane derivatives

Details Serine protease inhibitors-cycloheptane derivatives Serine protease inhibitors-cycloheptane derivatives

1997-12-04

2000-01-18

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514213, 514214, 514220, 514221, 530331, 540495, 540502, 540503, 540506, 540507, 540508, 540509, 540510, 540511, 540513, 540520, 540523, A61K 3155, A61K 3805, A61K 3806, C07K 5078

Patent

active

060157917

ABSTRACT:
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compounds of the invention are useful in treating conditions such as adult respiratory distress syndrome, septic shock, and multiple organ failure.

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