Process for producing L-tryptophan

Details Process for producing L-tryptophan Process for producing L-tryptophan

1994-05-18

1996-10-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

43523232, 4353201, 435 29, 435 60, 435 72, C12P 1372, C12N 1563, C12N 1577

Patent

active

055630529

ABSTRACT:
L-tryptophan is produced by constructing a recombinant DNA composed of a vector DNA and DNA fragments bearing all of genetic information relating to the synthesis of DS, AS, PRT, PRAI, InGPS and TS, introducing the recombinant DNA in a microorganism belonging to the genus Corynebacterium or Brevibacterium, culturing the microorganism in a medium, and recovering L-tryptophan accumulated in the culture.

REFERENCES:
Shiio, I. et. al., Agric. Biol. Chem., vol. 46, No. 7 (1982) pp. 1849-1854.
Sugimoto, S. and Shiio, I., Agric. Biol. Chem., vol. 49, vol. 1 (1985) pp. 39-48.
Patent Abstracts of Japan, vol. 10, No. 345 (1986) p. 2401.
E. Tribe & J. Pittard, 1979, "Hyperproduction of Tryptophan by Escherchia coli: Genetic Manipulation of the Pathways Leading to Tryptophan Formulation", Applied & Environmental Microbiology, vol. 38, pp. 181-190.
S. Aiba et al., 1982, "New Approach to Tryptophan Production by Eschericha coli: Genetic Manipulation of Composite Plasmids In Vitro", Applied & Environmental Microbiology, vol. 43, pp. 289-297.

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