Method and compositions for topical application of ascorbic acid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424 59, 424 60, A61K 3120, A61K 742

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active

055740634

ABSTRACT:
A method for the therapeutic treatment of skin disorders of the type directly or indirectly caused by collagen deficiency, and/or oxygen-containing free radicals and/or by oxidative generation of biologically active metabolites, in which a fat-soluble fatty acid ester of ascorbic acid is topically applied to the affected skin areas, preferably in association with a dermatologically acceptable carrier. Tocotrienols or tocotrienol derivatives and/or .alpha.-hydroxy acids may be incorporated in the compositions to enhance efficacy for certain conditions. Periodontal disease is also treated or prevented by the topical application to the mouth of fatty acid esters of ascorbic acid. Ascorbyl palmitate is employed in some embodiments.

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Perricone, N., J. Ger. Derm. 1:5-10 (1993).
Smart, R. C., and Crawford, C. L., Am. J. Clin. Nutr. 54:1266S-73S (1991).

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