Methods for inhibiting angiogenesis proliferation of endothelial

Details Methods for inhibiting angiogenesis proliferation of endothelial Methods for inhibiting angiogenesis proliferation of endothelial

1994-12-13

1996-11-12

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

514154, 514765, A61K 3165, A61K 31025

Patent

active

055740260

ABSTRACT:
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-halogen-9-[hydrogen or [(substituted glycyl)amido]]-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein X and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.

REFERENCES:
patent: 3226436 (1965-12-01), Petisi et al.
patent: 3518306 (1970-06-01), Martell et al.
patent: 5248797 (1993-09-01), Sum
patent: 5268384 (1993-12-01), Galardy
Guerin C. et al, Selective Endothelial Growth Inhibition by Tetracyclines that Inhibit Collagenase, Biochemical and Biophysical Research Communications, vol. 188, No. 2, 740-745, 1992.
Bogert C. van den, Arrest of in Vivo Proliferation of Zajdela Tumor Cells by Inhibition of Mitochondrial Protein Synthesis, Cancer Research 41, 1943-1947, May 1981.
Teicher, B. A. et al, Antiangiogenic Agents Potentiate Cytotoxic Cancer Therapeis against Primary and Metastatic Disease, Cancer Research, 52, 6702-6704, Dec., 1992.
Monks, A. et al, Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines, Journal of the National Cancer Institute, vol. 83, No. 11, 757-766, Jun., 1991.
Sotomayor, E. A. et al, Minocycline in combination with chemotherapy or radiation therapy in vitro and in vivo, Cancer Chemotherapy and Pharmacology, 30:377-384, 1992.
Leezenberg, J. A. et al, Possible Cytostatic Action of Tetracyclines in the Treatment of Tumors of the Nasopharynx and Larynx, European Journal of Clinical Pharmacology, 16, 237-241, 1979.
Tamargo, R. et al, Angiogenesis Inhibition by Minocycline, Cancer Research, 51, 672-675, Jan., 1991.
Kroon, A. M., The Antitumour Action of Doxycycline, Drugs Exptl. Clin. Res., X (11), 759-766, 1984.
Bogert C. van den, Arrest of the Proliferation of Renal and Prostate Carcinomas of Human Origin by Inhibition of Mitochondrial Protein Synthesis, Cancer Research, 46, 3283-3289, Jul., 1986.
Pruzandki, W. et al, Inhibition of Enzymatic Activity of Phospholipases A.sub.2 by Minocycline and Doxycycline, Biochemical Pharmacology, vol. 44, No. 6, 1165-1170, 1992.
Golub, L. M. et al, Host Modulation with Tetracyclines and their Chemically Modified Analogues, Periodontology and Restorative Dentistry, 80-90, 1992.
Golub, L. M. et al, Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs, Critical Reviews in Oral Biology and Medicine, 2(2):297-322 (1991).
Kajigaeshi, S. et al, Iodination of Phenols by use of Benzyltrimethylammonium Dichloroiodate (10).sup.1), Chemistry Letters, (Japan) 2109-2112, 1987.
Kajigaeshi, S. et al, Hologenation Using Quaternary Ammonium Polyhalides. VI..sup.1) Bromination of Aromatic Amines by Use of Benzyltrimethylammonium Tribromide Bull Chem. Soc. Jpn., 61, 597-599, 1988.
Zucker, S. et al, Diversity of Melanoma Plasma Membrane Proteinases: Inhibition of Collagenoloytic and Cytoltic Activities by Minocycline, JNCI> vol. 75, No. 3, Sep. 1985.
Greenwald R. A., et al, Tetracyclines Inhibit Human Synovial Collagenase In Vivo and In Vitro, The Journal of Rhematology 1987: 14:1.
Hlavka, J. Et al, The 6-Deoxytetracyclines. III. Electrophilic and Nucleophilic Substitution J. Am.Chem Soc., 84, 1420, 1962.

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