Intramolecularly crosslinked (1.fwdarw.3)-.beta.-D-glucans

Details Intramolecularly crosslinked (1.fwdarw.3)-.beta.-D-glucans Intramolecularly crosslinked (1.fwdarw.3)-.beta.-D-glucans

1995-01-06

1996-11-12

Naff, David M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435101, 536 186, A01N 4304, A61K 31715, C07G 300, C12P 1904

Patent

active

055740235

ABSTRACT:
The invention stabilizes single helix conformation (1.fwdarw.3)-.beta.-D-glucans by intramolecular crosslinking and provides (1.fwdarw.3)-.beta.-D-glucans showing stable biological activities. Thus, intramolecularly crosslinked (1.fwdarw.3)-.beta.-D-glucans having a stable single helix conformation are produced by introducing a functional group into hydroxyl groups of (1.fwdarw.3)-.beta.-D-glucans, then causing the thus-obtained functional glucans to take a single helix conformation, and subjecting these, either as such or after binding them to a receptor therefor, to intramolecular crosslinking between the functional groups introduced, if necessary followed by releasing the receptor therefrom.

REFERENCES:
patent: 4835265 (1989-05-01), Muzzarelli
patent: 4863907 (1989-09-01), Sakurai et al.
Jun Aketagawa et al "Activation of Limulus Coagulation Factor G by Several (1.fwdarw.3)-.beta.-D-Glucans: Comparison of the Potency of Glucans with Identical Degree of Polymerization but Different Conformations" J. Biochem. 113:683-686 (1993).
Chibara, G., Yakugaku Zasshi, 108(3), 171-186 (1988).
Saito, H. et al., Macromolecules, 11(6), 1244-1251 (1978).
Morita, T. et al., FEBS Letters, 129(2), 318-321 (1981).
Ochiai, M. et al., J. Biol. Chem., 263(24), 12056-12062 (1988).
Czop, J. K. et al., J. Immunol., 141(9), 3170-3176 (1988).
Yanaki, T. et al., Agric. Biol. Chem., 50(9), 2415-2416 (1986).
Saito, H. et al., XVth International Carbohydrate Symposium; Aug. 12-17, p. 289 (1990).
Ohno, N. et al., Carbohydrate Research, 207, 311-318 (1990).
Saito, H. et al., Carbohydrate Research, 217, 181-190 (1991).
Tanaka, S. et al., Carbohydrate Research, 218, 167-174 (1991).

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