Peptide compound and a process for the preparation thereof

Details Peptide compound and a process for the preparation thereof Peptide compound and a process for the preparation thereof

1995-05-22

1996-11-12

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514822, 562444, 562448, 530331, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

055740162

ABSTRACT:
The present invention concerns glycoprotein IIa/IIIb antagonists and platelet aggregation inhibitors of the formula (I): ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s),

REFERENCES:
patent: 4857508 (1989-08-01), Adams et al.
patent: 5039805 (1991-08-01), Alig et al.
Die Pharmazie, vol. 39, No. 6, 1988, pp. 412-414, B. Voigt, et al., "Synthese Von N.alpha.-(Arylsulfonyl)-4-Amidino-Phenylalanyl-Prolinen und Von N.alpha.-(Arylsulfonylglycyl)-4-Amidino-Phenylalanyl-prolinen und deren prufung Als Inhibitoren von Serinproteinasen".
Die Pharmazie, vol. 39, No. 2, 1984, pp. 82-84, H. Vieweg, et al., "Synthese von N.alpha.-Tosyl -4-Amidinophenylalaninderivaten mit Zwei C-Terminal Eingeschobenen Aminosauren ALS Potentielle Inhibitoren von Serinproteinasen".
Chemistry and Biochemistry of Amino Acids and Proteinsvol. 7 Spatola, Edited by Boris Neinstein (Marcel Dekkern 1983) pp. 267-357.
Walsman et al. Pharmazie37(6):457 (1982) Translated pp. 1-4.
Rudtinger, Peptide Hormones(ed. J. A. Parsons) (Univ. Press 1976) pp. 1-7.
Pierschbacher et al. J. Biol. Chem. vol. 262 No. 36 pp. 17294-17298.

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