Process for the enzymatic preparation of GRF(1-44)NH.sub.2

Details Process for the enzymatic preparation of GRF(1-44)NH.sub.2 Process for the enzymatic preparation of GRF(1-44)NH.sub.2

1995-06-05

1996-10-08

Rollins, John W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 694, 514 12, 530324, 930120, C12P 2106, A61K 3700

Patent

active

055630448

ABSTRACT:
GRF(1-44)-NH.sub.2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH.sub.2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides an economical pathway to the clinically important GRF(1-44)-NH.sub.2 compound.

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