Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1995-06-05
2000-01-18
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
424489, 424490, 424491, 424497, 424499, 424501, 264 41, 264 44, 4272133, 42721331, 427236, A61K 4904, A61K 950, B01J 1302
Patent
active
060155469
ABSTRACT:
Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcaspsules.
Suitable wall-forming materials include proteins such as albumin and gelatin.
The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilization and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.
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Johnson Richard Alan
Sutton Andrew Derek
Dees Jos,e G.
Hartley Michael G.
Quadrant Healthcare (UK) Limited
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