Use of amidoamines in ophthalmic compositions

Chemical apparatus and process disinfecting – deodorizing – preser – Process disinfecting – preserving – deodorizing – or sterilizing – Using disinfecting or sterilizing substance

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424 7804, 514840, 510112, A01N 3302, A61L 218, C11D 330, A61K 3113

Patent

active

055737269

ABSTRACT:
The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described, Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described, The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.

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Muzyczko, T. M., et al., "Fatty Amidoamine Derivatives: N,N-Dimethyl-N-(3-alkylamidopropyl)amines and Their Salts," Journal of the American Oil Chemists' Society, vol. 45, No. 11, pp. 720-725 (1968).
Devinsky, F., et al., "N-(dimethyl)ammino) alkyldodecanamides", Chemical Abstracts, vol. 105, No. 23, Dec. 8, 1986, abstract No. 208483.
Limanov, V., et al., "Synthesis and bactericidal activity of quaternary (N-acylaminoproyl) ammonium salts", Chemical Abstracts, vol. 95, No. 7, pp. 28-30, Aug. 1981, abstract No. 61431.
Block, Seymour S. Disinfection, Sterilization, and Preservation, 4th ed, 1991. p. 232.

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