Monensin urethane derivatives

Details Monensin urethane derivatives Monensin urethane derivatives

1979-09-20

1981-04-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 424181, 435 72, 435 84, 536 17R, 536 18, 536 53, C07H 308

Patent

active

042634270

ABSTRACT:
Monensin urethane derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, wherein R.sub.4 is alkyl, aryl, alkylaryl, arylalkyl, haloaryl, nitroaryl, haloarylalkyl, alkoxyaryl, aryloxyaryl, arylcycloalkyl, acylaryl and cycloalkyl; R.sub.2 is methyl or ethyl and R.sub.3 is --CONHR.sub.4 and their pharmaceutically acceptable salts.
The compounds exhibit antimicrobial activity and activity as growth promotant agents in ruminants. Further activities for this series of compounds are anticoccidial activity, antihypertensive activity, antimalarial activity and as agents in the treatment of swine dysentery.
Also disclosed are a fermentative process and a semisynthetic process for producing the urethane derivatives.

REFERENCES:
patent: 4125709 (1978-11-01), Smith
patent: 4138481 (1979-02-01), Martin et al.
Noller "Chem. of Organic Compounds", 3rd Ed., W. B. Saunders Co., Phila., Pa., 1965, pp. 338-339.
"Chemical Abstracts", vol. 70, 1969, pp. 2040g.

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