Pyridyl-and/or pyridoyl-(piperid-4-yl) ureas and analogues there

Details Pyridyl-and/or pyridoyl-(piperid-4-yl) ureas and analogues there Pyridyl-and/or pyridoyl-(piperid-4-yl) ureas and analogues there

1988-10-19

1991-01-15

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 514314, 546139, 546146, 546148, 546152, 546153, 546155, 546156, 546174, 546175, A61K 31445, C07D40112, C07D40100

Patent

active

049854380

ABSTRACT:
The invention concerns the preparation of compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula ##STR2## in which Q is O, S, --CR.sup.7 .dbd.CR.sup.8 --, --N.dbd.CR.sup.8 -- and --N.dbd.N--; R.sup.4, R.sup.5 and R.sup.6 ; and R.sup.7 and R.sup.8 when present, each represent hydrogen or a substitutent selected from lower alkyl, lower alkenyl, lower alkoxy, NO.sub.2, NH.sub.2, haloloweralkyl, hydroxyloweralkyl, aminoloweralkyl, substituted amino, halogen, loweralkoxycarbonyl, cyano, CONH.sub.2 and hydroxy; and additionally either R.sup.4 and R.sup.5 when adjacent or R.sup.6 and R.sup.8 when adjacent, together with the carbon atoms to which they are attached also represent a fused five or six membered carbocylic or heterocyclic ring optionally carrying one or more substituents as defined above; R is an optionally substituted aryl or heteroaryl radical or a cycloalkyl radical containing 5 to 7 carbon atoms; R.sup.1, R.sup.2, R.sup.3 and R.sup.9 are each hydrogen or a lower alkyl group; n is 0 or 1; X is .dbd.O, .dbd.S or .dbd.NH; Y is--O-- or a direct bond and Z is --CO-- or --CH.sub.2 --, with the proviso that when Ar is unsubstituted phenyl and R.sup.9 is hydrogen then y is --O--. The compounds of formula I exhibit psychotropic activity and are useful as antidepressants.

REFERENCES:
patent: 4073790 (1978-02-01), Archibald et al.
patent: 4177279 (1979-12-01), Archibald et al.
patent: 4199590 (1980-04-01), Ward
patent: 4209521 (1980-06-01), Archibald et al.
patent: 4235915 (1980-11-01), Archibald et al.
patent: 4281132 (1981-07-01), Ward
patent: 4425343 (1984-01-01), Sakata et al.
patent: 4569933 (1986-02-01), Cornu et al.
patent: 4704390 (1987-11-01), Caprathe et al.
patent: 4778802 (1988-10-01), Archibald et al.
Carey and Sundberg, Advanced Organic Chomistry, Part A, (Plenum Press, New York) 1924 pp. 496-7.
Foye, Principals of Medicinal Chemistry (Lea and Febiger Philadelphia, 1981) p. 34.
Irikura et al., Chem. Abst., 78, 159433a: (1973).
Arimura, Katsuo et al., Chem. Abst., 88, 22640c, (1978).

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