Cephalosporin vinyl halides

Details Cephalosporin vinyl halides Cephalosporin vinyl halides

1981-03-30

1982-06-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 28, C07D50118

Patent

active

043340644

ABSTRACT:
7-Acylamido-2-halomethylidene-3-methyl and 3-acetoxymethyl-3-cephem-4-carboxylic acids and esters are prepared via reaction of the corresponding 2-exomethylene-3-cephem ester sulfoxides with chloro (or bromo) dimethyliminium chlorides (or bromides). The 2-halomethylidene derivatives are useful as antimicrobial agents and intermediates to novel 2-acyloxy-methylidene cephalosporins and to the known 2-aryl (or alkyl) mercaptomethylidene cephalosporins.

REFERENCES:
patent: 3578660 (1971-05-01), Cooper
patent: 3660396 (1972-05-01), Wright
patent: 3852282 (1974-12-01), Dolfini
patent: 3923795 (1975-12-01), Spry
patent: 3933806 (1976-01-01), Spry
patent: 3963712 (1976-06-01), Koyama
patent: 4098999 (1978-07-01), Dolfini
Wright et al., J. Med. Chem. 14 420-425 (1971).
Kaiser et al., J. Med. Chem. 14 426-429 (1971).

Affiliated with

Also associated with

Rating

Cephalosporin vinyl halides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cephalosporin vinyl halides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin vinyl halides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-553866