Cephalosporin vinyl halides

Details Cephalosporin vinyl halides Cephalosporin vinyl halides

1981-03-30

1982-06-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 16, 544 30, 544 22, C07D50120

Patent

active

043340636

ABSTRACT:
7-Acylamido-2-halomethylidene-3-methyl and 3-acetoxymethyl-3-cephem-4-carboxylic acids and esters are prepared via reaction of the corresponding 2-exomethylene-3-cephem ester sulfoxides with chloro (or bromo) dimethyliminium chlorides (or bromides). The 2-halomethylidene derivatives are useful as antimicrobial agents and intermediates to novel 2-acyloxymethylidene cephalosporins and to the known 2-aryl (or alkyl) mercaptomethylidene cephalosporins.

REFERENCES:
patent: 3578660 (1971-05-01), Cooper
patent: 3660396 (1972-05-01), Wright
patent: 3852282 (1974-12-01), Dolfini
patent: 4299954 (1981-11-01), Spry

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