Silylated arabino-base compounds

Details Silylated arabino-base compounds Silylated arabino-base compounds

1980-10-20

1982-06-08

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, C07H 1906

Patent

active

043340598

ABSTRACT:
Silylated arabino-base compounds of the general formula: ##STR1## in which B represents an optionally substituted purine or pyrimidine base (cytosine, guanine, uracil, thymine or adenine) and one at least of R, R' and R" is alkylsilyl, the others being hydrogen, show activity as antiviral agents, especially in combatting herpes simplex virus. The preferred alkylsilyl group is tert. butyldimethylsilyl.

REFERENCES:
patent: 4055717 (1977-10-01), Baker et al.
patent: 4090021 (1978-05-01), Vorbruggen
patent: 4169943 (1979-10-01), Vorbruggen
Chemical Abstract, vol. 87, p. 11, Abst. No. 15695a, 1977.
"Relationship of Structure and Antiviral Activity of 9-.beta.-D-Arabinofuranosyladenine Analogs", Haskell, Ann. N.Y. Acad. Sci., 1977, 284, 81-90.

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