Prolonged release of biologically active polypeptides

Details Prolonged release of biologically active polypeptides Prolonged release of biologically active polypeptides

1988-06-29

1991-01-15

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 12, 514 21, 514492, 514494, 514499, 514501, 514502, 514503, 514505, 530399, 530400, A61K 3714, A61K 3324, A61K 3330, C07K 1300

Patent

active

049854046

ABSTRACT:
Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the polypeptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.

REFERENCES:
patent: 4256737 (1981-03-01), Nestor et al.
patent: 4452775 (1984-06-01), Kent
patent: 4610976 (1986-09-01), Bohlen et al.
Machlin, J. Animal Science, vol. 35, No. 4, (1972), pp. 794-800.

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