Substituted imidazoles and their use

Details Substituted imidazoles and their use Substituted imidazoles and their use

1981-02-11

1982-06-08

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

542400, 542457, 542458, 542468, C07C23396

Patent

active

043339476

ABSTRACT:
The invention provides compounds of the formula: ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R.sub.4 is hydrogen or alkyl of 1 to 7 carbon atoms; and n is 0-3; and their non-toxic pharmaceutically acceptable acid addition salts. These compounds exhibit valuable pharmacological activity and are useful in the treatment of mammals, e.g. as anti-hypertensive, .beta.-blocking and anti-thrombotic agents. Furthermore the compounds have remarkable antimicrobial activity. The compounds may be made by a variety of methods and may be incorporated in pharmaceutical compositions also comprising a compatible pharmaceutically acceptable carrier.

REFERENCES:
patent: 3050520 (1962-08-01), Erner et al.
patent: 3502661 (1970-03-01), Kasubick et al.
patent: 3812111 (1974-05-01), Wehrmeister
patent: 3991201 (1976-11-01), Heeres et al.
patent: 4238497 (1980-12-01), Black et al.
patent: 4273783 (1981-06-01), Diethelm

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